Our Roots Are Nearly 100 Years Old!

Pathology reference lab was officially founded in 2000, however, it's roots go back to 1922 with Dr. John Moore, who was San Antonio's first full time pathologist.

Our foundation began with and is based on total commitment to outstanding service and support.  Our group has been committed to providing a high degree of personalized service to each patient and physician. We have striven for excellence in all aspects of our service.

Since then, our group has continued to grow to the amazing organization it is now.  Our laboratory consists of over 30 Board certified pathologists and 100 employees, including a seasoned team of cytotechnologists, histotechnologists, sales, and support staff.  Each member in our organization is a part of the team and plays a vital role in delivering diagnostic excellence.  We are proud to say many of our employees have been with us for many years, with a few working with us over 20 years. 

We believe the key to our success begins and ends with the partnership between the pathologist, the healthcare provider, and the patient.  Pathology Reference Laboratory is dedicated to providing the highest quality technical and medical professional services to patients and the healthcare providers we are privileged to serve.


  • PRL is owned by physician pathologists, so you can be sure YOUR and your PATIENT'S best interests are at heart!

  • Send specimens with ease - whether you are local or elsewhere in Texas with free specimen pick-up/shipping

  • We accept all insurances - making our lab an easy choice.

  • Fast turn around time - routine cases are signed out in 24 hours.

  • Availability - a pathologist is always available to talk with you.

  • Connectivity - We can interface with your EMR or print reports in your office. Additionally, the physician can always access current and historic pathology data 24 hours a day on PHYSICIAN ACCESS LINK (PAL), a web-based order entry and result retrieval product that is available to all clients with broadband connectivity. 

  • Billing - Our billing is handled expertly by our own bilingual billing staff, and we provide fair and equitable payment plans to all patients.



Although we are based in San Antonio, TX, we are proud to be a regional leader in pathology diagnostic services for both physicians and hospitals alike.  Some of our clients include:

  • The Christus Hospital System

  • TexSan Hospital

  • Metropolitan Methodist  Hospital

  • Hill Country Memorial Hospital

  • Peterson Regional Medical Center

  • Doctor's Hospital of Laredo

  • Additional locations in Houston, Corpus Christi, and Abilene...